Neutrophil elastase inhibitor purification strategy from cowpea seeds
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چکیده
منابع مشابه
neutrophil elastase inhibitor following liver resection: a matched cohort study
background sivelestat is a neutrophil elastase inhibitor (nei) with positive impact on the respiratory complications in thoracic surgery. based on the findings of a recent study, nei may have a good response for avoiding ischemia reperfusion injury in liver resection. conclusions intravenous nei administration had positive impact on the postoperative inflammatory response and oxygenation while ...
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Proteinase inhibitor PI9 (PI9) is an intracellular 42-kDa member of the ovalbumin family of serpins that is found primarily in placenta, lung and lymphocytes. PI9 has been shown to be a fast-acting inhibitor of granzyme B in vitro, presumably through the utilization of Glu(340) as the P(1) inhibitory residue in its reactive site loop. In this report, we describe the inhibition of human neutroph...
متن کاملNeutrophil Elastase Inhibitor Following Liver Resection: A Matched Cohort Study.
BACKGROUND Sivelestat is a neutrophil elastase inhibitor (NEI) with positive impact on the respiratory complications in thoracic surgery. Based on the findings of a recent study, NEI may have a good response for avoiding ischemia reperfusion injury in liver resection. OBJECTIVES The current study aimed to examine the impact of NEI on the postoperative outcomes after liver resection. PATIENT...
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Protease inhibitors were extracted from the seeds of Lavatera cashmeriana Camb by ammonium sulphate precipitation and purified by chromatography on DEAE-cellulose and Sephadex G-100 column. The bound protein eluted into four major peaks which we named as LC-pi I, II, III and IV, all showing strong anti protease activity against trypsin, chymotrypsin and elastase. LC-pi I was screened for antiba...
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The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systema...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0223713